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Sunday sees the first Wear-Tyne derby since 2024, but which side will celebrate – the Black Cats or Newcastle?
"During the bulk of last season, you couldn't have imagined Sunderland rising to the top flight and being competitive with Eddie Howe's Newcastle, let alone being above them in the table," remarked analyst Chris Sutton.
"Things are very different now, and the way Sunderland play makes me think they've got a genuine opportunity."
He is offering scoreline guesses for all 380 Premier League games this season, in competition with artificial intelligence, fans and a variety of guests.
For week 16, he takes on England Gaming star Daniel 'Stingray' Ray.
Ray is vying for victory for the England's esports team – the Football Association's recognised esports team – at the gaming title Uefa eEuro 2025 finals tournament, which is being held at Twickenham Stadium on Saturday.
You can watch Uefa's YouTube, Instagram Live and TikTok channels, as well as the official Twitch channel and YouTube and the national team's Twitch.
Do you agree with their forecasts? Share your own predictions below.
The fan-favourite scoreline picked for each game is featured in the leaderboards at the foot of this page.
A correct result (choosing a win, draw or defeat) is worth ten points. The exact score earns 40 points.
Ray, who competes for his club side and the Premier League champions as well as England, is entering the fray at the eEuros finals after getting through the preliminary stage.
A group of eight will fly the flag at the finals in a straight knockout, competing for a six-figure prize fund and a prestigious spot in the world finals play-offs, with the Danish representative Anders Vejrgang defending the title he won last year.
"I am feeling really good for it," Ray stated. "There's a really good coach with me and preparation has been going well.
"It's always an honour to play for your country. Naturally when you are younger, you imagine doing it as an actual footballer, but when you pursue a career in this field and there is an chance to represent England, putting the shirt on is something incredible.
"I beat Vejrgang 9-4 in qualifying to get here. I've played against him throughout the year just in practice, and in other tournaments before - but I'd not previously defeated him in a tournament before.
"I believe he is the best player in the world so getting a win over him in a tournament like this just delivers a huge surge of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The London club were excellent against Arsenal at the end of November, when they earned a stalemate after going down to 10 men, and many thought this is it, they could possibly be title contenders.
Since then, however, they were beaten physically by Leeds, looked lethargic against Bournemouth and this week got defeated by Atalanta in the Champions League.
So head coach Enzo Maresca desperately requires a win here to get back on track, but it is a tough ask because Everton are such a threatening team.
Kiernan Dewsbury-Hall and Iliman Ndiaye are playing really well and they have got a bit of a positive run at the moment.
On form you would likely back Everton, while the most sensible prediction would likely be a draw, but I'm going against logic.
They have not given me any real reason to back them recently, but I just have a feeling they will take this one because they are at home and they are due a win.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I'm attending this game and it will be fascinating to see what we get from the Reds.
I am really pleased for Reds boss Arne Slot to get such a important victory at Inter Milan on Tuesday following all the stuff with Mohamed Salah this week.
Slot should not have to put up with that nonsense. I know Salah has been a great for the club but essentially Slot just wants to win games and there is no ulterior motive in his team selection.
They changed their formation against Inter and went with a midfield diamond formation and two up top.
All the talk is going to be talking about whether Salah is selected for this game, but the only way he is going to be brought back into the fold is if he apologises.
Slot's attention will be on winning this game, but it is a challenging encounter.
One might suggest it is the same for most teams but I find Brighton so mercurial. I always feel they have got a goal in them, but they are vulnerable at the back too.
Liverpool need to get back to a consistent run of form, but I am not sure how much their exertions at the San Siro will have drained them.
I put a couple of Brighton players in my FPL team, so they will probably lose now - but I do think they can get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
Sunderland have had the week off while Newcastle had to exert themselves against Bayer Leverkusen on Wednesday, only to be pegged back late on.
Aside from their excellent performance against Everton a couple of weeks ago, Newcastle's away form hasn't been great, especially straight after they've played in the Champions League.
I am expecting that pattern to continue on Sunday, and their tiredness is likely to be a significant issue in how this game goes because of Sunderland's energetic style.
We saw how unwavering Regis le Bris's side are. They dominated the Gunners, and it was a joy to watch.
Commentators talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been excellent, but Noah Sadiki, who plays alongside him, has also been one of the best acquisitions and should be recognised too.
All signs point to this being the best game|most exciting fixture